Shoppers swarmed into the Oxford street flagship store to be the first to get their hands on the Madonna originals.
The singer teamed with designer Margareta van den Bosch to create the new line and commented, "Working with H&M was an exciting and new creative challenge. I'm happy with the results and look forward to wearing M by Madonna along with the rest of the world".
The clothing collection consists of jackets, blazers, blouses, dresses, bags and sunglasses.
Bosch added, "Madonna has an impressive feel for fashion and she was extraordinarily conscious, passionate and involved in even the smallest details".